How to Take Rubraca® (rucaparib) tablets
How to take Rubraca
How to take Rubraca

How do I take Rubraca?

Take 2 Rubraca tablets 2 times a day

  • Starting dose is 600 mg (two 300-mg tablets) taken twice daily, about 12 hours apart
  • With or without food
Dosing
Dosing

Take Rubraca exactly as your oncologist tells you

Your oncology healthcare team is the best source of information about how you’re doing on your treatment. Don’t forget to speak up and ask your oncologist questions at each visit or to call if you need an answer right away.

  • Do not change your dose or stop taking Rubraca unless your oncologist tells you to
  • If you miss a dose, take your next dose at your usually scheduled time. Do not take an extra dose to make up for a missed dose
  • If you vomit after taking a dose, do not take an extra dose. Take your next dose at the usual time
  • If you take too much Rubraca, call your oncologist or go to the nearest emergency room right away

Your oncologist may lower your dose or stop treatment for a time if you have side effects.

Strength
Strength

Tablets shown are not actual size.

Dosing
Dosing

Helpful tips to consider when taking Rubraca

When to Take
  • Making Rubraca part of your mealtime routine to help you remember when to take your medication (at the same times each day)
  • Using a pillbox and putting it in a place where you can easily see it
  • Setting an alarm to remind you when to take your medication

How to store Rubraca

How to Store
  • Store Rubraca at room temperature at 68oF to 77oF (20oC to 25oC)
  • Keep Rubraca and all medicines out of the reach of children

Find out about the possible side effects of Rubraca

side effects Learn more

Learn about helpful support and resources for Rubraca

rubraca-connections Learn more

Download an informational brochure about Rubraca as maintenance therapy

Brochure Download

INDICATIONS

What is Rubraca?

Rubraca® (rucaparib) tablets are a prescription medicine used for:

  • the maintenance treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapy
  • the treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rubraca is right for you

It is not known if Rubraca is safe and effective in children. 

SELECT IMPORTANT SAFETY INFORMATION

Read full

warning Rubraca tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rubraca. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rubraca.

warning Symptoms of low blood cell counts are common during treatment with Rubraca but can be a sign of serious problems, including MDS or AML. Tell your healthcare provider if you have any of the following symptoms during treatment with Rubraca:

  • weakness
  • weight loss
  • fever
  • frequent infections
  • blood in urine or stool
  • shortness of breath
  • feeling very tired
  • bruising or bleeding more easily

warning Your healthcare provider will do blood tests before, and every month during treatment with Rubraca to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rubraca until your blood cell counts improve. 

warning Before you take Rubraca, tell your healthcare provider about all of your medical conditions, including if you:

warning

  • are pregnant or plan to become pregnant. Rubraca can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rubraca.
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rubraca.
    • Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rubraca.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant.

warning

  • are breastfeeding or plan to breastfeed. It is not known if Rubraca passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rubraca. Talk to your healthcare provider about the best way to feed your baby during this time.

warning Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

warning  While taking Rubraca, avoid spending time in sunlight.  Rubraca can make your skin sensitive to the sun (photosensitivity).  You may burn more easily during treatment with Rubraca. You should wear a hat and clothes that cover your skin and use sunscreen to help protect against sunburn if you have to be in the sunlight.

warning The most common side effects of Rubraca include:

  • nausea 
  • tiredness or weakness
  • vomiting
  • decrease in hemoglobin (anemia)
  • changes in how food tastes
  • constipation
  • decrease in appetite 
  • diarrhea
  • low blood cell counts
  • mouth sores
  • upper respiratory tract infection
  • shortness of breath
  • rash
  • changes in liver or kidney function blood tests
  • stomach (abdomen) pain
  • increased cholesterol levels

warning These are not all of the possible side effects of Rubraca. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

warning  You may report side effects to the FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Clovis Oncology, Inc. at 1‑415‑409‑7220 (US toll) or 1‑844‑CLVS‑ONC (1‑844‑258‑7662; US toll-free).

Please see full Prescribing Information, including Patient Information, for additional Important Safety Information.

INDICATIONS

What is Rubraca?

Rubraca® (rucaparib) tablets are a prescription medicine used for:

  • the maintenance treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapy
  • the treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rubraca is right for you

It is not known if Rubraca is safe and effective in children. 

SELECT IMPORTANT SAFETY INFORMATION

Read full

warning Rubraca tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rubraca. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rubraca.

warning Symptoms of low blood cell counts are common during treatment with Rubraca but can be a sign of serious problems, including MDS or AML. Tell your healthcare provider if you have any of the following symptoms during treatment with Rubraca:

  • weakness
  • weight loss
  • fever
  • frequent infections
  • blood in urine or stool
  • shortness of breath
  • feeling very tired
  • bruising or bleeding more easily

warning Your healthcare provider will do blood tests before, and every month during treatment with Rubraca to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rubraca until your blood cell counts improve. 

warning Before you take Rubraca, tell your healthcare provider about all of your medical conditions, including if you:

warning

  • are pregnant or plan to become pregnant. Rubraca can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rubraca.
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rubraca.
    • Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rubraca.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant.

warning

  • are breastfeeding or plan to breastfeed. It is not known if Rubraca passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rubraca. Talk to your healthcare provider about the best way to feed your baby during this time.

warning Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

warning  While taking Rubraca, avoid spending time in sunlight.  Rubraca can make your skin sensitive to the sun (photosensitivity).  You may burn more easily during treatment with Rubraca. You should wear a hat and clothes that cover your skin and use sunscreen to help protect against sunburn if you have to be in the sunlight.

warning The most common side effects of Rubraca include:

  • nausea 
  • tiredness or weakness
  • vomiting
  • decrease in hemoglobin (anemia)
  • changes in how food tastes
  • constipation
  • decrease in appetite 
  • diarrhea
  • low blood cell counts
  • mouth sores
  • upper respiratory tract infection
  • shortness of breath
  • rash
  • changes in liver or kidney function blood tests
  • stomach (abdomen) pain
  • increased cholesterol levels

warning These are not all of the possible side effects of Rubraca. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

warning  You may report side effects to the FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Clovis Oncology, Inc. at 1‑415‑409‑7220 (US toll) or 1‑844‑CLVS‑ONC (1‑844‑258‑7662; US toll-free).

Please see full Prescribing Information, including Patient Information, for additional Important Safety Information.