How to Manage Possible Side Effects | Rubraca® (rucaparib) tablets
Side Effects
Side Effects

Managing possible side effects with Rubraca

When taking Rubraca, discuss how you are feeling with your oncology healthcare team. They may be able to give you tips and/or change your dose to help with side effects you may be experiencing.

Consider these tips to help with the most common side effects of Rubraca

The following tips are from the National Cancer Institute and the American Cancer Society and are not specific to Rubraca. Here are some of the most common side effects (reported by at least 20% of women) associated with Rubraca. They do not include all the possible side effects. Before you make any changes, be sure to talk with your oncology healthcare team.

Tell a member of your oncology healthcare team about any side effects before you stop taking Rubraca. Your oncologist may temporarily lower your dose or stop treatment with Rubraca. Always follow the instructions from your oncology healthcare team.

If you are experiencing nausea and vomiting…

nausea and vomiting

You may want to consider the following:

  • Eating small, frequent meals or all-liquid meals

  • Choosing foods that are easy on the stomach (such as dry toast and crackers)

  • Serving meals at room temperature

  • Asking your oncology healthcare team about antiemetics or antinausea medication that may help with nausea and vomiting

If you are constipated…

Constipation

You may want to consider the following:

  • Drinking plenty of fluids each day, especially warm or hot fluids, may help with bowel movements

  • Trying to eat more high-fiber foods such as raw fruits and vegetables, raisins, prunes, and dates

  • Trying not to eat foods that cause gas (like cabbage or broccoli) or could make your constipation worse (like cheese or eggs)

  • Talking to a member of your oncology healthcare team before using medicines for constipation

If you have diarrhea…

diarrhea

You may want to consider the following:

  • Eating more foods that are high in sodium and potassium (including bananas, oranges, boiled or mashed potatoes, and peach or apricot nectar), because you lose these important nutrients when you have diarrhea

  • Drinking 8 to 12 cups of clear liquids each day and avoiding acidic drinks like tomato juice, citrus juices, and soft drinks

  • Talking to your oncology healthcare team before taking any over-the-counter medicines to control your diarrhea

  • Recording the number of loose or runny stools you experience daily. Your oncology healthcare team may prescribe medication to control your diarrhea

If you’re feeling tired or weak (fatigued)…

fatigue

You may want to consider the following:

  • Balancing your daily routine with both rest and physical activity. Try light exercise every day, with plenty of short naps or breaks

  • Joining a support group to help alleviate some of the mental stress that can contribute to feeling tired or weak

If you have changes in taste or smell…

Taste or Smell

You may want to consider the following:

  • Avoiding foods that don’t appeal to you

  • Marinating or adding extra flavors to improve tastes

  • Using plastic forks and spoons if you have a metal taste in your mouth

  • Avoiding unpleasant smells by keeping food covered

If you have decreased appetite…

decreased appetite

You may want to consider the following:

  • Eating foods that are high in calories and easy to eat (such as pudding, ice cream, sherbet, or cream-based soups)

  • Eating 6 to 8 small meals or snacks each day instead of 3 big meals

  • Eating with other family members and creating a pleasant ambiance at meals

  • Doing some light exercise an hour before meals

  • Having liquid meals, such as flavored smoothies or milkshakes

If you have abdominal (stomach-area) pain…

abdominal pain

You may want to consider the following:

  • Practicing deep breathing, yoga, or other ways to relax

  • Asking your oncology healthcare team about pain medicines that may help. Do not take any medicine for pain without first asking your team

  • Using a pain rating scale, such as 0 = no pain to 10 = the worst pain you can imagine, to help explain your pain to others. This can be particularly helpful when talking to a member of your oncology healthcare team

How to take Rubraca

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Download your personal diary for taking notes on your Rubraca experience

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Find out about the possible side effects of Rubraca

Side Effects Learn more

INDICATIONS

What is Rubraca?

Rubraca® (rucaparib) tablets are a prescription medicine used for:

  • the maintenance treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapy
  • the treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rubraca is right for you

It is not known if Rubraca is safe and effective in children. 

SELECT IMPORTANT SAFETY INFORMATION

Read full

warning Rubraca tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rubraca. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rubraca.

warning Symptoms of low blood cell counts are common during treatment with Rubraca but can be a sign of serious problems, including MDS or AML. Tell your healthcare provider if you have any of the following symptoms during treatment with Rubraca:

  • weakness
  • weight loss
  • fever
  • frequent infections
  • blood in urine or stool
  • shortness of breath
  • feeling very tired
  • bruising or bleeding more easily

warning Your healthcare provider will do blood tests before, and every month during treatment with Rubraca to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rubraca until your blood cell counts improve. 

warning Before you take Rubraca, tell your healthcare provider about all of your medical conditions, including if you:

warning

  • are pregnant or plan to become pregnant. Rubraca can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rubraca.
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rubraca.
    • Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rubraca.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant.

warning

  • are breastfeeding or plan to breastfeed. It is not known if Rubraca passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rubraca. Talk to your healthcare provider about the best way to feed your baby during this time.

warning Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

warning  While taking Rubraca, avoid spending time in sunlight.  Rubraca can make your skin sensitive to the sun (photosensitivity).  You may burn more easily during treatment with Rubraca. You should wear a hat and clothes that cover your skin and use sunscreen to help protect against sunburn if you have to be in the sunlight.

warning The most common side effects of Rubraca include:

  • nausea 
  • tiredness or weakness
  • vomiting
  • decrease in hemoglobin (anemia)
  • changes in how food tastes
  • constipation
  • decrease in appetite 
  • diarrhea
  • low blood cell counts
  • mouth sores
  • upper respiratory tract infection
  • shortness of breath
  • rash
  • changes in liver or kidney function blood tests
  • stomach (abdomen) pain
  • increased cholesterol levels

warning These are not all of the possible side effects of Rubraca. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

warning  You may report side effects to the FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Clovis Oncology, Inc. at 1‑415‑409‑7220 (US toll) or 1‑844‑CLVS‑ONC (1‑844‑258‑7662; US toll-free).

Please see full Prescribing Information, including Patient Information, for additional Important Safety Information.

INDICATIONS

What is Rubraca?

Rubraca® (rucaparib) tablets are a prescription medicine used for:

  • the maintenance treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapy
  • the treatment of adults with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rubraca is right for you

It is not known if Rubraca is safe and effective in children. 

SELECT IMPORTANT SAFETY INFORMATION

Read full

warning Rubraca tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rubraca. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rubraca.

warning Symptoms of low blood cell counts are common during treatment with Rubraca but can be a sign of serious problems, including MDS or AML. Tell your healthcare provider if you have any of the following symptoms during treatment with Rubraca:

  • weakness
  • weight loss
  • fever
  • frequent infections
  • blood in urine or stool
  • shortness of breath
  • feeling very tired
  • bruising or bleeding more easily

warning Your healthcare provider will do blood tests before, and every month during treatment with Rubraca to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rubraca until your blood cell counts improve. 

warning Before you take Rubraca, tell your healthcare provider about all of your medical conditions, including if you:

warning

  • are pregnant or plan to become pregnant. Rubraca can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rubraca.
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rubraca.
    • Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rubraca.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant.

warning

  • are breastfeeding or plan to breastfeed. It is not known if Rubraca passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rubraca. Talk to your healthcare provider about the best way to feed your baby during this time.

warning Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

warning  While taking Rubraca, avoid spending time in sunlight.  Rubraca can make your skin sensitive to the sun (photosensitivity).  You may burn more easily during treatment with Rubraca. You should wear a hat and clothes that cover your skin and use sunscreen to help protect against sunburn if you have to be in the sunlight.

warning The most common side effects of Rubraca include:

  • nausea 
  • tiredness or weakness
  • vomiting
  • decrease in hemoglobin (anemia)
  • changes in how food tastes
  • constipation
  • decrease in appetite 
  • diarrhea
  • low blood cell counts
  • mouth sores
  • upper respiratory tract infection
  • shortness of breath
  • rash
  • changes in liver or kidney function blood tests
  • stomach (abdomen) pain
  • increased cholesterol levels

warning These are not all of the possible side effects of Rubraca. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

warning  You may report side effects to the FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Clovis Oncology, Inc. at 1‑415‑409‑7220 (US toll) or 1‑844‑CLVS‑ONC (1‑844‑258‑7662; US toll-free).

Please see full Prescribing Information, including Patient Information, for additional Important Safety Information.