Resources for men taking Rubraca
Organizations supporting men, family members, and caregivers impacted by BRCA+ metastatic castration-resistant prostate cancer
Please note: All logos are registered trademarks of their specific organizations.
Clovis Oncology is not affiliated with and does not endorse any of the listed organizations. The information and resources available on these sites reflect the opinions and recommendations of the individual organizations only.
Antiemetics/antinausea medication: drugs taken to prevent or treat nausea and vomiting.
Blood-based biopsy: also called a liquid biopsy. A type of biopsy done on a blood sample to look for either DNA or cancer cells from a tumor that are circulating in the blood.
BRCA: stands for breast cancer susceptibility gene.
BRCA+: term used to describe a patient who has a BRCA gene mutation.
BRCA gene mutation: a break in the BRCA1 or BRCA2 gene that normally aids in repairing cell DNA damage; BRCA gene mutations can be inherited (germline) or acquired spontaneously (somatic).
Castration-resistant prostate cancer: prostate cancer that no longer responds to drug or surgical treatments to lower testosterone.
Chemotherapy: a type of cancer treatment that uses drugs to eliminate cancer cells. Rubraca is approved for patients following the use of a taxane-based chemotherapy which is commonly given through a slow injection into a vein.
Clinical study: research that is designed to test new medical approaches, such as new medicines, and find out if they work and are safe for people.
DNA (deoxyribonucleic acid): molecules that tell your cells how to survive and grow.
Genes: a set of coded instructions in cells for making new proteins and controlling how cells behave.
Germline BRCA mutation: also called an inherited mutation, meaning the gene mutation is passed down from parent to child. Germline mutations are present in every cell in the body, not just in the tumor cells.
mCRPC (metastatic castration-resistant prostate cancer): prostate cancer that has spread to other parts of the body and that no longer responds to drug or surgical treatments to lower testosterone.
Metastatic prostate cancer: prostate cancer that has spread to other parts of the body.
Mutation: a change in the DNA sequence.
PARP inhibitor (PARPi) (poly (ADP-ribose) polymerase inhibitor): medication that blocks PARP, a protein that helps repair DNA when it becomes damaged. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors may also impact other cells and tissues.
Response: therapeutic effect of treatment.
Side effect: a problem that may occur when treatment affects healthy tissues or organs.
Somatic BRCA mutation: also called an acquired mutation, meaning the gene mutation is not passed down from parent to child, but occurs randomly and can develop at any time. Somatic mutations are only present in the tumor cells.