BRCA gene mutations play an important role in mCRPC
Rubraca is for men with BRCA gene mutations. Everyone has BRCA1 and BRCA2 genes, which play an important role in normal day-to-day functions of cells. Some men, however, may have “broken” BRCA genes, called mutations. BRCA gene mutations increase the likelihood of developing certain cancers, including prostate cancer, and may help your doctor anticipate the aggressiveness of your disease and evaluate treatment options.
There are 2 types of BRCA gene mutations:
- Inherited (also called germline), meaning the gene mutation is passed down from parent to child. Germline mutations are present in every cell in the body, not just in the tumor cells
- Acquired (also called somatic), meaning the gene mutation is not passed down from parent to child, but occurs randomly and can develop at any time. Somatic mutations are only present in the tumor cells
If you have a family history of certain types of cancers, including prostate cancer, you may have a greater likelihood of carrying a BRCA gene mutation.
There are several tests to detect BRCA gene mutations that will determine if you are a potential candidate for Rubraca
- While some tests are designed to look for inherited BRCA gene mutations or for acquired BRCA mutations, other tests can look for both. Your doctor will recommend the test that is right for you
- Your doctor might see if Rubraca is right for you by doing a blood test, called a blood-based biopsy (or liquid biopsy). This test is less invasive than a tissue biopsy and can identify both inherited and acquired BRCA gene mutations